Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70–Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells

Asymmetric dimethylarginine (ADMA) induces the mitochondrial translocation of endothelial nitric oxide synthase (eNOS) through the nitration-mediated activation of Akt1. However, it is recognized that the activation of Akt1 requires phosphorylation events at threonine (T) 308 and serine (S) 473. Thu...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Sun, Xutong, Kellner, Manuela, Desai, Ankit A., Wang, Ting, Lu, Qing, Kangath, Archana, Qu, Ning, Klinger, Christina, Fratz, Sohrab, Yuan, Jason X.-J., Jacobson, Jeffrey R., Garcia, Joe G. N., Rafikov, Ruslan, Fineman, Jeffrey R., Black, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979361/
https://ncbi.nlm.nih.gov/pubmed/26959555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0185OC
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