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CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells
BACKGROUND: Age-related cataract (ARC) is the leading cause of visual impairment worldwide, and α-crystallin (CRYAA) is the predominant structural protein involved in the maintenance of lens clarity and refractive properties. We previously demonstrated that CRYAA genes undergo epigenetic repression...
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| Publicado no: | BMC Ophthalmol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4979130/ https://ncbi.nlm.nih.gov/pubmed/27507241 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12886-016-0309-y |
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