Improved PCR based methods for detecting C9orf72 hexanucleotide repeat expansions

Due to the GC-rich, repetitive nature of C9orf72 hexanucleotide repeat expansions, PCR based detection methods are challenging. Several limitations of PCR have been reported and overcoming these could help to define the pathogenic range. There is also a need to develop improved repeat-primed PCR ass...

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Опубликовано в: :Mol Cell Probes
Главные авторы: Cleary, Elaine M., Pal, Suvankar, Azam, Tara, Moore, David J., Swingler, Robert, Gorrie, George, Stephenson, Laura, Colville, Shuna, Chandran, Siddharthan, Porteous, Mary, Warner, Jon P.
Формат: Artigo
Язык:Inglês
Опубликовано: Academic Press 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978699/
https://ncbi.nlm.nih.gov/pubmed/27288208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcp.2016.06.001
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