Improved PCR based methods for detecting C9orf72 hexanucleotide repeat expansions

Due to the GC-rich, repetitive nature of C9orf72 hexanucleotide repeat expansions, PCR based detection methods are challenging. Several limitations of PCR have been reported and overcoming these could help to define the pathogenic range. There is also a need to develop improved repeat-primed PCR ass...

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Detalhes bibliográficos
Publicado no:Mol Cell Probes
Main Authors: Cleary, Elaine M., Pal, Suvankar, Azam, Tara, Moore, David J., Swingler, Robert, Gorrie, George, Stephenson, Laura, Colville, Shuna, Chandran, Siddharthan, Porteous, Mary, Warner, Jon P.
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978699/
https://ncbi.nlm.nih.gov/pubmed/27288208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcp.2016.06.001
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