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Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21
A detailed understanding of the molecular mechanisms whereby ubiquitin (Ub) recognizes enzymes in the Ub proteasome system is crucial for understanding the biological function of Ub. Many structures of Ub complexes have been solved and, in most cases, reveal a large structural epitope on a common fa...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4978272/ https://ncbi.nlm.nih.gov/pubmed/27436899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524648113 |
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