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Effects of xanthine oxidase inhibition with febuxostat on the development of nephropathy in experimental type 2 diabetes

BACKGROUND AND PURPOSE: Elevated serum uric acid (UA) is a risk factor for the development of kidney disease. Inhibitors of xanthine oxidase (XOi), an enzyme involved in UA synthesis, have protective effects at early stages of experimental diabetic nephropathy (DN). However, long‐term effects of XOi...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Komers, Radko, Xu, Bei, Schneider, Jennifer, Oyama, Terry T
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4978156/
https://ncbi.nlm.nih.gov/pubmed/27238746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13527
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