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2-(Maleimidomethyl)-1,3-Dioxanes (MD): a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation

The vast majority of antibody-drug conjugates (ADC) are prepared through amine-to-thiol conjugation. To date, N-Succinimidyl-4-(maleimidomethyl) cyclohexanecarboxylate (SMCC) has been one of the most frequently applied reagents for the preparation of ADC and other functional conjugates. However, SMC...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Dovgan, Igor, Kolodych, Sergii, Koniev, Oleksandr, Wagner, Alain
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977557/
https://ncbi.nlm.nih.gov/pubmed/27501860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30835
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