Wiz binds active promoters and CTCF-binding sites and is required for normal behaviour in the mouse

We previously identified Wiz in a mouse screen for epigenetic modifiers. Due to its known association with G9a/GLP, Wiz is generally considered a transcriptional repressor. Here, we provide evidence that it may also function as a transcriptional activator. Wiz levels are high in the brain, but its f...

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Vydáno v:eLife
Hlavní autoři: Isbel, Luke, Prokopuk, Lexie, Wu, Haoyu, Daxinger, Lucia, Oey, Harald, Spurling, Alex, Lawther, Adam J, Hale, Matthew W, Whitelaw, Emma
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Genes and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4977153/
https://ncbi.nlm.nih.gov/pubmed/27410475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15082
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