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Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype

The number of reports of paternal epigenetic influences on the phenotype of offspring in rodents is increasing but the molecular events involved remain unclear. Here, we show that haploinsufficiency for the histone 3 lysine 9 methyltransferase Setdb1 in the sire can influence the coat colour phenoty...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Daxinger, Lucia, Oey, Harald, Isbel, Luke, Whitelaw, Nadia C., Youngson, Neil A., Spurling, Alex, Vonk, Kelly K. D., Whitelaw, Emma
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845014/
https://ncbi.nlm.nih.gov/pubmed/27112447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25004
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