Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

Flaviviruses comprise major emerging pathogens such as dengue virus (DENV) or Zika virus (ZIKV). The flavivirus RNA genome is replicated by the RNA-dependent-RNA polymerase (RdRp) domain of non-structural protein 5 (NS5). This essential enzymatic activity renders the RdRp attractive for antiviral th...

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Detaylı Bibliyografya
Yayımlandı:PLoS Pathog
Asıl Yazarlar: Lim, Siew Pheng, Noble, Christian Guy, Seh, Cheah Chen, Soh, Tingjin Sherryl, El Sahili, Abbas, Chan, Grace Kar Yarn, Lescar, Julien, Arora, Rishi, Benson, Timothy, Nilar, Shahul, Manjunatha, Ujjini, Wan, Kah Fei, Dong, Hongping, Xie, Xuping, Shi, Pei-Yong, Yokokawa, Fumiaki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976923/
https://ncbi.nlm.nih.gov/pubmed/27500641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005737
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