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Complex negative regulation of TLR9 by multiple proteolytic cleavage events

Toll like receptor 9 (TLR9) is an innate immune receptor important for recognizing DNA, both of host and foreign origin. A mechanism proposed to prevent excessive response to host DNA is the requirement for proteolytic cleavage of TLR9 in endosomes to generate a mature form of the receptor (TLR9(471...

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Publicado en:J Immunol
Autores principales: Sinha, Siddhartha S., Cameron, Jody, Brooks, James C., Leifer, Cynthia A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976034/
https://ncbi.nlm.nih.gov/pubmed/27421483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502357
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