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TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA
Toll-like receptor 9 (TLR9) promiscuously binds self and microbial DNA, but only microbial DNA elicits an inflammatory response. How TLR9 discriminates between self and foreign DNA is unclear, but inappropriate localization of TLR9 permits response to self DNA, suggesting that TLR9 localization and...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2753824/ https://ncbi.nlm.nih.gov/pubmed/19079358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2008.101 |
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