TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA

Toll-like receptor 9 (TLR9) promiscuously binds self and microbial DNA, but only microbial DNA elicits an inflammatory response. How TLR9 discriminates between self and foreign DNA is unclear, but inappropriate localization of TLR9 permits response to self DNA, suggesting that TLR9 localization and...

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Main Authors: Chockalingam, Annapoorani, Brooks, James C., Cameron, Jody L., Blum, Lisa K., Leifer, Cynthia A.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753824/
https://ncbi.nlm.nih.gov/pubmed/19079358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2008.101
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