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Negative Self-Regulation of TLR9 Signaling by Its N-Terminal Proteolytic Cleavage Product

TLR signaling is essential to innate immunity against microbial invaders and must be tightly controlled. We have previously shown that TLR9 undergoes proteolytic cleavage processing by lysosomal proteases to generate two distinct fragments. The C-terminal cleavage product plays a critical role in ac...

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Dettagli Bibliografici
Pubblicato in:J Immunol
Autori principali: Lee, Sungwook, Kang, Dongju, Ra, Eun A., Lee, Taeyun A., Ploegh, Hidde L., Park, Boyoun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285150/
https://ncbi.nlm.nih.gov/pubmed/25187653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400210
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