B cell intrinsic T-bet expression is required to control chronic viral infection

The role of antibody and B cells in preventing infection is established. In contrast, the role of B cell responses in containing chronic infections remains poorly understood. IgG2a (IgG1 in humans) can prevent acute infections and T-bet promotes IgG2a isotype switching. However, whether IgG2a and B...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Barnett, Burton E., Staupe, Ryan P., Odorizzi, Pamela M., Palko, Olesya, Tomov, Vesselin T., Mahan, Alison E., Gunn, Bronwyn, Chen, Diana, Paley, Michael A., Alter, Galit, Reiner, Steven L., Lauer, Georg M., Teijaro, John, Wherry, E. John
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975981/
https://ncbi.nlm.nih.gov/pubmed/27430722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500368
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