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Small Molecule Ligands for Bulged RNA Secondary Structures

A class of wedge-shaped small molecules has been designed, synthesized, and shown to bind bulged RNA secondary structures. These minimally cationic ligands exhibit good affinity and selectivity for certain RNA bulges as demonstrated in a fluorescent intercalator displacement assay. [Image: see text]

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Meyer, S. Todd, Hergenrother, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975938/
https://ncbi.nlm.nih.gov/pubmed/19678613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol901478x
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