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Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics

The reactive dicarbonyl metabolite methylglyoxal (MG) is the precursor of the major quantitative advanced glycation endproducts (AGEs) in physiological systems - arginine-derived hydroimidazolones and deoxyguanosine-derived imidazopurinones. The glyoxalase system in the cytoplasm of cells provides t...

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Publicat a:Glycoconj J
Autors principals: Rabbani, Naila, Xue, Mingzhan, Thornalley, Paul J.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975768/
https://ncbi.nlm.nih.gov/pubmed/27406712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10719-016-9705-z
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