Interactions of Pleckstrin Homology Domains with Membranes: Adding Back the Bilayer via High-Throughput Molecular Dynamics

A molecular simulation pipeline for determining the mode of interaction of pleckstrin homology (PH) domains with phosphatidylinositol phosphate (PIP)-containing lipid bilayers is presented. We evaluate our methodology for the GRP1 PH domain via comparison with structural and biophysical data. Coarse...

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Detalles Bibliográficos
Publicado en:Structure
Main Authors: Yamamoto, Eiji, Kalli, Antreas C., Yasuoka, Kenji, Sansom, Mark S.P.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2016
Assuntos:
Theory
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975593/
https://ncbi.nlm.nih.gov/pubmed/27427480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.06.002
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