Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein

Single-domain antibodies derived from the unique New Antigen Receptor found in sharks have numerous potential applications, ranging from diagnostic reagents to therapeutics. Shark-derived single-domain antibodies possess the same characteristic ability to refold after heat denaturation found in sing...

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Udgivet i:PLoS One
Main Authors: Anderson, George P., Teichler, Daniel D., Zabetakis, Dan, Shriver-Lake, Lisa C., Liu, Jinny L., Lonsdale, Stephen G., Goodchild, Sarah A., Goldman, Ellen R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4975481/
https://ncbi.nlm.nih.gov/pubmed/27494523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160534
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