Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal

Cancer stem cells (CSCs) have key roles in treatment resistance, tumour metastasis and relapse. Using colorectal cancer (CC) cell lines, patient-derived xenograft (PDX) tissues and patient tissues, here we report that CC CSCs, which resist chemoradiation, have higher SUMO activating enzyme (E1) and...

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Vydáno v:Nat Commun
Hlavní autoři: Du, Li, Li, Yi-Jia, Fakih, Marwan, Wiatrek, Rebecca L., Duldulao, Marjun, Chen, Zhenbin, Chu, Peiguo, Garcia-Aguilar, Julio, Chen, Yuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974481/
https://ncbi.nlm.nih.gov/pubmed/27465491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12326
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