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TP53 and Let-7a micro-RNA Regulate K-Ras Activity in HCT116 Colorectal Cancer Cells

Recent reports have indicated that KRAS and TP53 mutations predict response to therapy in colorectal cancer. However, little is known about the relationship between these two common genetic alterations. Micro-RNAs (miRNAs), a class of noncoding RNA implicated in cellular processes, have been increas...

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Detalhes bibliográficos
Main Authors: Luu, Carrie, Heinrich, Eileen L., Duldulao, Marjun, Arrington, Amanda K., Fakih, Marwan, Garcia-Aguilar, Julio, Kim, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731270/
https://ncbi.nlm.nih.gov/pubmed/23936455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070604
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