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Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions

The serine/threonine kinase tumor progression locus 2 (Tpl2, also known as Map3k8/Cot) is a potent inflammatory mediator that drives the production of TNFα, IL-1β, and IFNγ. We previously demonstrated that Tpl2 regulates T cell receptor (TCR) signaling and modulates T helper cell differentiation. Ho...

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書誌詳細
出版年:J Biol Chem
主要な著者: Li, Xin, Acuff, Nicole V., Peeks, Angela R., Kirkland, Rebecca, Wyatt, Kara D., Nagy, Tamas, Watford, Wendy T.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974392/
https://ncbi.nlm.nih.gov/pubmed/27261457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.718783
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