Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling

Glycosylation can exert a profound impact on the structures and biological functions of antibodies. Glycosylation remodeling using the endoglycosidase-catalyzed deglycosylation and transglycosylation approach is emerging as a promising platform to produce homogeneous glycoforms of antibodies, but th...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Li, Tiezheng, Tong, Xin, Yang, Qiang, Giddens, John P., Wang, Lai-Xi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2016
Gaiak:
Glycobiology and Extracellular Matrices
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974367/
https://ncbi.nlm.nih.gov/pubmed/27288408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.738765
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