Mitochondrial Dynamics Controls T Cell Fate Through Metabolic Programming

Activated effector T (T(E)) cells augment anabolic pathways of metabolism, such as aerobic glycolysis, while memory T (T(M)) cells engage catabolic pathways, like fatty acid oxidation (FAO). However, signals that drive these differences remain unclear. Mitochondria are metabolic organelles that acti...

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Publicat a:Cell
Autors principals: Buck, Michael D., O’Sullivan, David, Klein Geltink, Ramon I., Curtis, Jonathan D., Chang, Chih-Hao, Sanin, David E., Qiu, Jing, Kretz, Oliver, Braas, Daniel, van der Windt, Gerritje J.W., Chen, Qiongyu, Ching-Cheng Huang, Stanley, O’Neill, Christina M., Edelson, Brian T., Pearce, Edward J., Sesaki, Hiromi, Huber, Tobias B., Rambold, Angelika S., Pearce, Erika L.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974356/
https://ncbi.nlm.nih.gov/pubmed/27293185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.05.035
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