Metabolic competition in the tumor microenvironment is a driver of cancer progression

Failure of T cells to protect against cancer is thought to result from lack of antigen recognition, chronic activation, and/or suppression by other cells. Using a mouse sarcoma model, we show that glucose consumption by tumors metabolically restricts T cells, leading to their dampened mTOR activity,...

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Udgivet i:Cell
Main Authors: Chang, Chih-Hao, Qiu, Jing, O’Sullivan, David, Buck, Michael D., Noguchi, Takuro, Curtis, Jonathan D., Chen, Qiongyu, Gindin, Mariel, Gubin, Matthew M., van der Windt, Gerritje J.W., Tonc, Elena, Schreiber, Robert D., Pearce, Edward J., Pearce, Erika L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864363/
https://ncbi.nlm.nih.gov/pubmed/26321679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.08.016
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