Mitochondrial Respiratory Capacity Is A Critical Regulator Of CD8(+) T Cell Memory Development

CD8(+) T cells undergo major metabolic changes upon activation, but how metabolism influences the establishment of long-lived memory T (T(M)) cells after infection remains a key question. We have shown here that CD8(+) T(M) cells, but not effector CD8(+) (T(E)) cells, possessed substantial mitochond...

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Main Authors: van der Windt, Gerritje J.W., Everts, Bart, Chang, Chih-Hao, Curtis, Jonathan D., Freitas, Tori C., Amiel, Eyal, Pearce, Edward J., Pearce, Erika L.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269311/
https://ncbi.nlm.nih.gov/pubmed/22206904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.12.007
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