HCV dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy

BACKGROUND/AIM: Legalon SIL (SIL) is a chemically hydrophilized version of silibinin, an extract of milk thistle (Silybum marianum) seeds that has exhibited hepatoprotective and antiviral effectiveness against hepatitis C virus (HCV) in patients leading to viral clearance in combination with ribavir...

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Bibliografiska uppgifter
I publikationen:J Viral Hepat
Huvudupphovsmän: DebRoy, Swati, Hiraga, Nobuhiko, Imamura, Michio, Hayes, C. Nelson, Akamatsu, Sakura, Canini, Laetitia, Perelson, Alan S., Pohl, Ralf T., Persiani, Stefano, Uprichard, Susan L., Tateno, Chise, Dahari, Harel, Chayama, Kazuaki
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974116/
https://ncbi.nlm.nih.gov/pubmed/27272497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jvh.12551
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