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Understanding silibinin’s modes of action against HCV using viral kinetic modeling

BACKGROUND & AIMS: Legalon® SIL (SIL) is a chemically hydrophilized version of silibinin that has exhibited high antiviral effectiveness against hepatitis C virus (HCV). Its main mode of action (MOA) remains unclear, with contradicting in-vitro studies supporting either suppression of entry and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Guedj, Jeremie, Dahari, Harel, Pohl, Ralf T., Ferenci, Peter, Perelson, Alan S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3328661/
https://ncbi.nlm.nih.gov/pubmed/22245888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2011.12.012
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