Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases

PURPOSE: Previous studies have shown that vitreous stimulates degradation of the tumor suppressor protein p53 and that knockdown of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Kα and -β) abrogates proliferation of p53-deficient cells. The purpose of this study was to determine whether vitreous...

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Vydáno v:Invest Ophthalmol Vis Sci
Hlavní autoři: Ma, Gaoen, Duan, Yajian, Huang, Xionggao, Qian, Cynthia X., Chee, Yewlin, Mukai, Shizuo, Cui, Jing, Samad, Arif, Matsubara, Joanne Aiko, Kazlauskas, Andrius, D'Amore, Patricia A., Gu, Shuyan, Lei, Hetian
Médium: Artigo
Jazyk:Inglês
Vydáno: The Association for Research in Vision and Ophthalmology 2016
Témata:
Biochemistry and Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4974024/
https://ncbi.nlm.nih.gov/pubmed/27472081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19405
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