Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase

Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty acid synthesis (FASII) pathway. In Toxoplasma gondii, the causative agent of toxoplasmosis, the FASII pathway is essentia...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Amiar, Souad, MacRae, James I., Callahan, Damien L., Dubois, David, van Dooren, Giel G., Shears, Melanie J., Cesbron-Delauw, Marie-France, Maréchal, Eric, McConville, Malcolm J., McFadden, Geoffrey I., Yamaryo-Botté, Yoshiki, Botté, Cyrille Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973916/
https://ncbi.nlm.nih.gov/pubmed/27490259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005765
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