Changes in protein structure monitored by use of gas‐phase hydrogen/deuterium exchange

The study of protein conformation by solution‐phase hydrogen/deuterium exchange (HDX) coupled to MS is well documented. This involves monitoring the exchange of backbone amide protons with deuterium and provides details concerning the protein's tertiary structure. However, undesired back‐exchan...

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Detaylı Bibliyografya
Yayımlandı:Proteomics
Asıl Yazarlar: Beeston, Helen S., Ault, James R., Pringle, Steven D., Brown, Jeffery M., Ashcroft, Alison E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2015
Konular:
Top down Intact Protein Analysis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973844/
https://ncbi.nlm.nih.gov/pubmed/25603979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201400440
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