Optimal Synthetic Glycosylation of a Therapeutic Antibody

Glycosylation patterns in antibodies critically determine biological and physical properties but their precise control is a significant challenge in biology and biotechnology. We describe herein the optimization of an endoglycosidase‐catalyzed glycosylation of the best‐selling biotherapeutic Hercept...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Parsons, Thomas B., Struwe, Weston B., Gault, Joseph, Yamamoto, Keisuke, Taylor, Thomas A., Raj, Ritu, Wals, Kim, Mohammed, Shabaz, Robinson, Carol V., Benesch, Justin L. P., Davis, Benjamin G.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973692/
https://ncbi.nlm.nih.gov/pubmed/26756880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508723
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