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Lung Epithelial Cell–Specific Expression of Human Lysosomal Acid Lipase Ameliorates Lung Inflammation and Tumor Metastasis in Lipa(−/−) Mice

Lysosomal acid lipase (LAL), a key enzyme in the metabolic pathway of neutral lipids, has a close connection with inflammation and tumor progression. One major manifestation in LAL-deficient (Lipa(−/−)) mice is an increase of tumor growth and metastasis associated with expansion of myeloid-derived s...

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Bibliografiske detaljer
Udgivet i:Am J Pathol
Main Authors: Zhao, Ting, Ding, Xinchun, Du, Hong, Yan, Cong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973654/
https://ncbi.nlm.nih.gov/pubmed/27461363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.04.014
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