Macrophage-Specific Expression of Human Lysosomal Acid Lipase Corrects Inflammation and Pathogenic Phenotypes in lal(−/−) Mice

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl esters and triglycerides to generate free fatty acids and cholesterol in the cell. The downstream metabolites of these compounds serve as hormonal ligands for nuclear receptors and transcription factors. Genetic ablation of the lal gene in the mouse...

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Detaylı Bibliyografya
Asıl Yazarlar: Yan, Cong, Lian, Xuemei, Li, Yuan, Dai, Ying, White, Amanda, Qin, Yulin, Li, Huimin, Hume, David A., Du, Hong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2006
Konular:
Regular Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698822/
https://ncbi.nlm.nih.gov/pubmed/16936266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051327
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