Macrophage-Specific Expression of Human Lysosomal Acid Lipase Corrects Inflammation and Pathogenic Phenotypes in lal(−/−) Mice

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl esters and triglycerides to generate free fatty acids and cholesterol in the cell. The downstream metabolites of these compounds serve as hormonal ligands for nuclear receptors and transcription factors. Genetic ablation of the lal gene in the mouse...

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Bibliographic Details
Main Authors: Yan, Cong, Lian, Xuemei, Li, Yuan, Dai, Ying, White, Amanda, Qin, Yulin, Li, Huimin, Hume, David A., Du, Hong
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2006
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Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698822/
https://ncbi.nlm.nih.gov/pubmed/16936266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051327
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