Reduced Krüppel-Like Factor 2 Aggravates Glomerular Endothelial Cell Injury and Kidney Disease in Mice with Unilateral Nephrectomy

Loss of functional nephrons induces compensatory glomerular hyperfiltration and hypertrophy, leading to the progression of chronic kidney disease. Krüppel-like factor 2 (KLF2), a shear-stress–inducible transcription factor, confers protection against endothelial injury. Because glomerular hyperfiltr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Pathol
Prif Awduron: Zhong, Fang, Mallipattu, Sandeep K., Estrada, Chelsea, Menon, Madhav, Salem, Fadi, Jain, Mukesh K., Chen, Hongyu, Wang, Yongjun, Lee, Kyung, He, John C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Investigative Pathology 2016
Pynciau:
Regular Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973653/
https://ncbi.nlm.nih.gov/pubmed/27317905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.03.018
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