Reduced Krüppel-Like Factor 2 Aggravates Glomerular Endothelial Cell Injury and Kidney Disease in Mice with Unilateral Nephrectomy

Loss of functional nephrons induces compensatory glomerular hyperfiltration and hypertrophy, leading to the progression of chronic kidney disease. Krüppel-like factor 2 (KLF2), a shear-stress–inducible transcription factor, confers protection against endothelial injury. Because glomerular hyperfiltr...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Zhong, Fang, Mallipattu, Sandeep K., Estrada, Chelsea, Menon, Madhav, Salem, Fadi, Jain, Mukesh K., Chen, Hongyu, Wang, Yongjun, Lee, Kyung, He, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2016
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973653/
https://ncbi.nlm.nih.gov/pubmed/27317905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.03.018
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