Reduced Krüppel-Like Factor 2 Aggravates Glomerular Endothelial Cell Injury and Kidney Disease in Mice with Unilateral Nephrectomy

Loss of functional nephrons induces compensatory glomerular hyperfiltration and hypertrophy, leading to the progression of chronic kidney disease. Krüppel-like factor 2 (KLF2), a shear-stress–inducible transcription factor, confers protection against endothelial injury. Because glomerular hyperfiltr...

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Udgivet i:Am J Pathol
Main Authors: Zhong, Fang, Mallipattu, Sandeep K., Estrada, Chelsea, Menon, Madhav, Salem, Fadi, Jain, Mukesh K., Chen, Hongyu, Wang, Yongjun, Lee, Kyung, He, John C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2016
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973653/
https://ncbi.nlm.nih.gov/pubmed/27317905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.03.018
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