Grafting voltage and pharmacological sensitivity in potassium channels

A classical voltage-gated ion channel consists of four voltage-sensing domains (VSDs). However, the roles of each VSD in the channels remain elusive. We developed a GVTDT (Graft VSD To Dimeric TASK3 channels that lack endogenous VSDs) strategy to produce voltage-gated channels with a reduced number...

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Bibliografiske detaljer
Udgivet i:Cell Res
Main Authors: Lan, Xi, Fan, Chunyan, Ji, Wei, Tian, Fuyun, Xu, Tao, Gao, Zhaobing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973326/
https://ncbi.nlm.nih.gov/pubmed/27174053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2016.57
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