A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin

Repair of DNA double-strand breaks (DSBs) must be properly orchestrated in diverse chromatin regions to maintain genome stability. The choice between two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombination (HR), is regulated by the cell cycle as well as chromatin...

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Foilsithe in:Genes Dev
Main Authors: Janssen, Aniek, Breuer, Gregory A., Brinkman, Eva K., van der Meulen, Annelot I., Borden, Sean V., van Steensel, Bas, Bindra, Ranjit S., LaRocque, Jeannine R., Karpen, Gary H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973294/
https://ncbi.nlm.nih.gov/pubmed/27474442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.283028.116
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