Hypoxic Preconditioning Inhibits Hypoxia-induced Apoptosis of Cardiac Progenitor Cells via the PI3K/Akt-DNMT1-p53 Pathway

Research has demonstrated that hypoxic preconditioning (HP) can enhance the survival and proliferation of cardiac progenitor cells (CPCs); however, the underlying mechanisms are not fully understood. Here, we report that HP of c-kit (+) CPCs inhibits p53 via the PI3K/Akt-DNMT1 pathway. First, CPCs w...

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Vydáno v:Sci Rep
Hlavní autoři: Xu, Rongfeng, Sun, Yuning, Chen, Zhongpu, Yao, Yuyu, Ma, Genshan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973228/
https://ncbi.nlm.nih.gov/pubmed/27488808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30922
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