PI3K–AKT Pathway Protects Cardiomyocytes Against Hypoxia-Induced Apoptosis by MitoKATP-Mediated Mitochondrial Translocation of pAKT

Background/Aims: The phosphatidylinositol-3-kinase -AKT (PI3K-AKT) is an important intracellular signal pathway in regulating cell proliferation, differentiation and apoptosis. In previous studies, we’ve demonstrated that PI3K–AKT pathway protects cardiomyocytes from ischemic and hypoxic apoptosis t...

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Main Authors: Hua-Pei Song, Zhi-Gang Chu, Dong-Xia Zhang, Yong-Ming Dang, Qiong Zhang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Sraith:Cellular Physiology and Biochemistry
Ábhair:
Pi3k–AKT
Cardiomyocytes
Hypoxic
Mitochondrial
MitoKATP
Apoptosis
Rochtain Ar Líne:https://www.karger.com/Article/FullText/493037
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