Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice

The C (-1019) G rs6295 promoter polymorphism of the serotonin-1A (5-HT1A) receptor gene is associated with major depression in several but not all studies, suggesting that compensatory mechanisms mediate resilience. The rs6295 risk allele prevents binding of the repressor Deaf1 increasing 5-HT1A rec...

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Detalhes bibliográficos
Publicado no:Mol Brain
Main Authors: Luckhart, Christine, Philippe, Tristan J., Le François, Brice, Vahid-Ansari, Faranak, Geddes, Sean D., Béïque, Jean-Claude, Lagace, Diane C., Daigle, Mireille, Albert, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973060/
https://ncbi.nlm.nih.gov/pubmed/27488351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-016-0254-y
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