Increased Serotonin-1A (5-HT1A) Autoreceptor Expression and Reduced Raphe Serotonin Levels in Deformed Epidermal Autoregulatory Factor-1 (Deaf-1) Gene Knock-out Mice

Altered regulation of the serotonin-1A (5-HT1A) receptor gene is implicated in major depression and mood disorders. The functional human 5-HT1A C(−1019)G promoter polymorphism (rs6295), which prevents the binding of Deaf-1/NUDR leading to dysregulation of the receptor, has been associated with major...

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Bibliographische Detailangaben
Hauptverfasser: Czesak, Margaret, Le François, Brice, Millar, Anne M., Deria, Mariam, Daigle, Mireille, Visvader, Jane E., Anisman, Hymie, Albert, Paul R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307310/
https://ncbi.nlm.nih.gov/pubmed/22232550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.293027
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