Loss of MeCP2 in adult 5-HT neurons induces 5-HT1A autoreceptors, with opposite sex-dependent anxiety and depression phenotypes

The 5-HT1A autoreceptor mediates feedback inhibition of serotonin (5-HT) neurons, and is implicated in major depression. The human 5-HT1A gene (HTR1A) rs6295 risk allele prevents Deaf1 binding to HTR1A, resulting in increased 5-HT1A autoreceptor transcription. Since chronic stress alters HTR1A methy...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Philippe, Tristan J., Vahid-Ansari, Faranak, Donaldson, Zoe R., Le François, Brice, Zahrai, Amin, Turcotte-Cardin, Valérie, Daigle, Mireille, James, Jonathan, Hen, René, Merali, Zul, Albert, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5893553/
https://ncbi.nlm.nih.gov/pubmed/29636529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24167-8
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