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Neddylation requires glycyl-tRNA synthetase to protect activated E2
Neddylation is a post-translational modification that controls cell cycle and proliferation by conjugating the ubiquitin-like protein NEDD8 to specific targets. Here we report that glycyl-tRNA synthetase (GlyRS), an essential enzyme for protein synthesis, also plays a critical role in neddylation. I...
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| Опубликовано в: : | Nat Struct Mol Biol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4972647/ https://ncbi.nlm.nih.gov/pubmed/27348078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3250 |
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