Neddylation requires glycyl-tRNA synthetase to protect activated E2

Neddylation is a post-translational modification that controls cell cycle and proliferation by conjugating the ubiquitin-like protein NEDD8 to specific targets. Here we report that glycyl-tRNA synthetase (GlyRS), an essential enzyme for protein synthesis, also plays a critical role in neddylation. I...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Mo, Zhongying, Zhang, Qian, Liu, Ze, Lauer, Janelle, Shi, Yi, Sun, Litao, Griffin, Patrick R., Yang, Xiang-Lei
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972647/
https://ncbi.nlm.nih.gov/pubmed/27348078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3250
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