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Crystal structure of the drug‐resistant S31N influenza M2 proton channel

The M2 protein is a small proton channel found in the influenza A virus that is necessary for viral replication. The M2 channel is the target of a class of drugs called the adamantanes, which block the channel pore and prevent the virus from replicating. In recent decades mutations have arisen in M2...

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Библиографические подробности
Опубликовано в: :Protein Sci
Главные авторы: Thomaston, Jessica L., DeGrado, William F.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972211/
https://ncbi.nlm.nih.gov/pubmed/27082171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2937
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