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Drug-Induced Conformational and Dynamical Changes of the S31N Mutant of the Influenza M2 Proton Channel Investigated by Solid-State NMR

The M2 protein of influenza A viruses forms a tetrameric proton channel that is targeted by the amantadine class of antiviral drugs. A S31N mutation in the transmembrane (TM) domain of the protein has caused widespread amantadine resistance in most of the currently circulating flu viruses. Recently,...

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Detalhes bibliográficos
Main Authors: Williams, Jonathan K., Tietze, Daniel, Wang, Jun, Wu, Yibing, DeGrado, William F., Hong, Mei
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004037/
https://ncbi.nlm.nih.gov/pubmed/23758317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4041412
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