Molecular and epigenetic features of melanomas and tumor immune microenvironment linked to durable remission to ipilimumab-based immunotherapy in metastatic patients

BACKGROUND: Ipilimumab (Ipi) improves the survival of advanced melanoma patients with an incremental long-term benefit in 10–15 % of patients. A tumor signature that correlates with this survival benefit could help optimizing individualized treatment strategies. METHODS: Freshly frozen melanoma meta...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Seremet, Teofila, Koch, Alexander, Jansen, Yanina, Schreuer, Max, Wilgenhof, Sofie, Del Marmol, Véronique, Liènard, Danielle, Thielemans, Kris, Schats, Kelly, Kockx, Mark, Van Criekinge, Wim, Coulie, Pierre G., De Meyer, Tim, van Baren, Nicolas, Neyns, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971660/
https://ncbi.nlm.nih.gov/pubmed/27484791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0990-x
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