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Interference in transcription of overexpressed genes by promoter-proximal downstream sequences

Despite a high sequence homology among four human RNAi-effectors Argonaute proteins and their coding sequences, the efficiency of ectopic overexpression of AGO3 and AGO4 coding sequences in human cells is greatly reduced as compared to AGO1 and AGO2. While investigating this phenomenon, we documente...

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Pubblicato in:Sci Rep
Autori principali: Turchinovich, A., Surowy, H. M., Tonevitsky, A. G., Burwinkel, B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971500/
https://ncbi.nlm.nih.gov/pubmed/27485701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30735
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