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Interference in transcription of overexpressed genes by promoter-proximal downstream sequences

Despite a high sequence homology among four human RNAi-effectors Argonaute proteins and their coding sequences, the efficiency of ectopic overexpression of AGO3 and AGO4 coding sequences in human cells is greatly reduced as compared to AGO1 and AGO2. While investigating this phenomenon, we documente...

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Vydáno v:Sci Rep
Hlavní autoři: Turchinovich, A., Surowy, H. M., Tonevitsky, A. G., Burwinkel, B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971500/
https://ncbi.nlm.nih.gov/pubmed/27485701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30735
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