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Potent transcriptional interference by pausing of RNA polymerases over a downstream promoter

Elongating RNA polymerases (RNAPs) can interfere with transcription from downstream promoters by inhibiting DNA binding by RNAP and activators. However, combining quantitative measurement with mathematical modelling, we show that simple RNAP elongation cannot produce the strong asymmetric interferen...

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Detalles Bibliográficos
Main Authors: Palmer, Adam C., Ahlgren-Berg, Alexandra, Egan, J. Barry, Dodd, Ian B., Shearwin, Keith E.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697128/
https://ncbi.nlm.nih.gov/pubmed/19524535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.04.018
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