Production of truncated MBD4 protein by frameshift mutation in DNA mismatch repair-deficient cells enhances 5-fluorouracil sensitivity that is independent of hMLH1 status

Methyl-CpG binding domain protein 4 (MBD4) is a DNA glycosylase that can remove 5-fluorodeoxyuracil from DNA as well as repair T:G or U:G mismatches. MBD4 is a target for frameshift mutation with DNA mismatch repair (MMR) deficiency, creating a truncated MBD4 protein (TruMBD4) that lacks its glycosy...

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Bibliographic Details
Published in:Cancer Biol Ther
Main Authors: Suzuki, Satoshi, Iwaizumi, Moriya, Tseng-Rogenski, Stephanie, Hamaya, Yasushi, Miyajima, Hiroaki, Kanaoka, Shigeru, Sugimoto, Ken, Carethers, John M.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970528/
https://ncbi.nlm.nih.gov/pubmed/27115207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2016.1178430
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